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CAS 131175-87-6
(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
Codes: (III)91299-1-a
Application context (from source-drug indications)
Plasmodium infectionArtesunate/Pyronaridine PhosphateCOVID-19Artesunate/Pyronaridine PhosphateFalciparum malariaArtesunate/Pyronaridine PhosphatePlasmodium infectionArtesunate/Mefloquine HydrochlorideFalciparum malariaArtesunate/Mefloquine HydrochloridePlasmodium infectionArtesunateIntestinal neoplasmArtesunateColon cancerArtesunateCervical intraepithelial neoplasiaArtesunateHIV infectionArtesunateCervical cancerArtesunate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Artesunate/Pyronaridine Phosphate | Tier C — Watch / trade | - |
| Artesunate/Mefloquine Hydrochloride | Tier C — Watch / trade | - |
| Artesunate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
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