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CAS 132327-80-1
(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid
Codes: (XII) 847759-1-b
Application context (from source-drug indications)
Metastatic breast cancerLutetium (177Lu) zaregreptide dizuxetanBreast cancerLutetium (177Lu) zaregreptide dizuxetanNeoplasmLutetium (177Lu) zaregreptide dizuxetanProstate cancerLutetium (177Lu) zaregreptide dizuxetanNeuroendocrine carcinomaLutetium (177Lu) zaregreptide dizuxetanSolid tumourLutetium (177Lu) zaregreptide dizuxetan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lutetium (177Lu) zaregreptide dizuxetan | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
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Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-alanyl-L-valylglycyl-1-(triphenylmethyl)-L-histidine→(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid→Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-alanyl-L-valylglycyl-1-(triphenylmethyl)-L-histidine→(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoic acid→Resin bound D-phenylalanyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-alanyl-L-valylglycyl-1-(triphenylmethyl)-L-histidine
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