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CAS 132629-37-9
ethyl (E)-2-styryloxazole-4-carboxylate
Codes: EDOX-027
Application context (from source-drug indications)
Pulmonary embolismEdoxaban Tosilate HydrateVenous thromboembolismEdoxaban Tosilate HydrateStrokeEdoxaban Tosilate HydrateEmbolismEdoxaban Tosilate HydrateVenous thrombosisEdoxaban Tosilate HydrateIschaemic strokeEdoxaban Tosilate Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Edoxaban Tosilate Hydrate | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→ethyl 3-bromo-2-oxopropanoate→cinnamamide→ethyl (E)-2-styryloxazole-4-carboxylate→(E)-2-styryloxazole-4-carbaldehyde→methyltriphenylphosphonium bromide→(E)-2-styryl-4-vinyloxazole→(E)-2-(2-styryloxazol-4-yl)ethan-1-ol→(E)-2-(2-(2-styryloxazol-4-yl)ethyl)isoindoline-1,3-dione→tert-butyl (E)-(2-(2-styryloxazol-4-yl)ethyl)carbamate→tert-butyl (E)-2-styryl-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-carboxylate→tert-butyl 2-formyl-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-carboxylate→5-(tert-butyl) 2-methyl 6,7-dihydrooxazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
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