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CAS 132958-72-6
(3R)-N,N-Dimethylpyrrolidin-3-amine
Codes: (VIIIa)1058685-1-a
Application context (from source-drug indications)
Non-small cell lung cancerSunvozertinibB-cell lymphomaSunvozertinibNon-Hodgkin lymphomaSunvozertinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Sunvozertinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Methyl 2-amino-4-chloro-5-fluorobenzoate→Bromo(methyl)magnesium→2-(2-Amino-4-chloro-5-fluorophenyl)propan-2-ol→2-Chloropyrimidin-4-yl chloride→2-[4-Chloro-2-[(2-chloropyrimidin-4-yl)amino]-5-fluorophenyl]propan-2-ol→2-Amino-5-fluoro-4-nitroanisole→2-(4-Chloro-5-fluoro-2-[[2-(4-fluoro-2-methoxy-5-nitroanilino)pyrimidin-4-yl]amino]phenyl)propan-2-ol→(3R)-N,N-Dimethylpyrrolidin-3-amine→(3R)-N,N-Dimethylpyrrolidin-3-amine hydrogen chloride (1/1)→2-[4-Chloro-2-[(2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-2-methoxy-5-nitroanilino]pyrimidin-4-yl)amino]-5-fluorophenyl]propan-2-ol→2-[2-[(2-[5-Amino-4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl)amino]-4-chloro-5-fluorophenyl]propan-2-ol→2-Propenoyl chloride→(Chloromethyl)acetyl chloride→3-Chloro-N-[5-([4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]propanamide
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