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CAS 1334429-35-4
1,3-Benzoxazol-6-yl(morpholin-4-yl)methanonebenzo[d]oxazol-6-yl(morpholino)methanone
Codes: (V)409139-2-a, TAFA-007
Application context (from source-drug indications)
Transthyretin amyloidosisTafamidisHeart diseaseTafamidisAmyloid polyneuropathyTafamidis MeglumineTransthyretin amyloidosisTafamidis MeglumineAmyloidosisTafamidis MeglumineCardiomyopathyTafamidis MeglumineLight-chain (AL) amyloidosisTafamidis MeglumineFamilial amyloid neuropathyTafamidis Meglumine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tafamidis | Tier C — Watch / trade | - |
| Tafamidis Meglumine | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4-Carboxy-2-hydroxyphenyl)amine→Orthoformic acid trimethyl ester→1,3-Benzoxazole-6-carboxylic acid→1,3-Benzoxazole-6-carbonyl chloride→1,3-Benzoxazol-6-yl(morpholin-4-yl)methanone→1,3-Dichloro-5-iodobenzene→[2-(3,5-Dichlorophenyl)-1,3-benzoxazol-6-yl]-morpholinomethanone→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
4-amino-3-hydroxybenzoic acid→benzo[d]oxazole-6-carboxylic acid→benzo[d]oxazol-6-yl(morpholino)methanone→1,3-dichloro-5-iodobenzene→(2-(3,5-dichlorophenyl)benzo[d]oxazol-6-yl)(morpholino)methanone
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