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CAS 134-11-2
2-ethoxybenzoic acid
Codes: AILDE-001, DIFAM-013
Application context (from source-drug indications)
Erectile dysfunctionAildenafil CitrateAtopic dermatitisDifamilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Aildenafil Citrate | Tier C — Watch / trade | - |
| Difamilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-ethoxybenzoic acid→5-(chlorosulfonyl)-2-ethoxybenzoyl chloride→(2R,6S)-2,6-dimethylpiperazine→5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxybenzoic acid→5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxybenzoyl chloride hydrochloride→4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide→4-(5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxybenzamido)-1-methyl-3-propyl-1H-pyrazole-5-carboxamide→5-(5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one→5-(5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate
ethyl 4-(benzyloxy)-3-hydroxybenzoate→4-(benzyloxy)-3-isopropoxybenzoic acid→4-(benzyloxy)-3-isopropoxybenzamide→ethyl 3-bromo-2-oxopropanoate→ethyl 2-(4-(benzyloxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-hydroxy-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanol→4-(bromomethyl)-2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole→potassium 1,3-dioxoisoindolin-2-ide→2-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanamine hydrochloride→2-ethoxybenzoic acid→N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide
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