CAS 13425-93-9

6,7-dimethoxyquinolin-4-ol

Codes: CABO-005

Application context (from source-drug indications)

Neuroendocrine tumourCabozantinib S-malatePancreatic neuroendocrine tumourCabozantinib S-malateRenal cell carcinomaCabozantinib S-malateHepatocellular carcinomaCabozantinib S-malateThyroid cancerCabozantinib S-malateNeuroendocrine carcinomaCabozantinib S-malate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Cabozantinib S-malate	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Cabozantinib S-malateOriginator routesteps: 7total yield: 3.2 g

1-(3,4-dimethoxyphenyl)ethan-1-one→1-(4,5-dimethoxy-2-nitrophenyl)ethanone→1-(2-amino-4,5-dimethoxyphenyl)ethanone→ethyl formate→6,7-dimethoxyquinolin-4-ol→6,7-dimethoxyquinolin-4-yl trifluoromethanesulfonate→N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide→cyclopropane-1,1-dicarboxylic acid→4-fluoroaniline→methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate→4-aminophenol

Cabozantinib S-malateProcess routesteps: 5total yield: 5.0 kg

ethyl formate→6,7-dimethoxyquinolin-4-ol→4-chloro-6,7-dimethoxyquinoline→4-nitrophenol→6,7-dimethoxy-4-(4-nitrophenoxy)quinoline→4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline→1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.