CAS 135048-32-7

2-cyanoisonicotinohydrazide

Codes: TOPI-004, TOPI-013

Application context (from source-drug indications)

HyperuricaemiaTopiroxostatGoutTopiroxostatDiabetic nephropathyTopiroxostat

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Topiroxostat	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

TopiroxostatOriginator routesteps: 4total yield: 3.66 g

4-carboxypyridine 1-oxide→4-(methoxycarbonyl)pyridine 1-oxide→methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile

TopiroxostatOptimised routesteps: 4total yield: /

4-carboxypyridine 1-oxide→isonicotinonitrile→4-(2-(tert-butoxycarbonyl)hydrazinecarbonyl)pyridine 1-oxide→tert-butyl 2-(2-cyanoisonicotinoyl)hydrazinecarboxylate→2-cyanoisonicotinohydrazide

TopiroxostatOptimised routesteps: 4total yield: 19 g

methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile→methyl isonicotinate→methyl 2-carbamoylisonicotinate

Intermediates available on this site

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