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CAS 1372609-22-7
(1E,5E)-4,4-difluoro-1-(tributylstannyl)octa-1,5-dien-3-ol
Codes: LUBI-033
Application context (from source-drug indications)
ConstipationLubiprostoneOpioid-induced constipationLubiprostoneChronic idiopathic constipationLubiprostoneDrug-related adverse effects and reactionsLubiprostoneNon-alcoholic steatohepatitisLubiprostonePeritoneal cancerLubiprostone
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lubiprostone | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 2-bromo-2,2-difluoroacetate→butyraldehyde→ethyl 2,2-difluoro-3-hydroxyhexanoate→ethyl (E)-2,2-difluorohex-3-enoate→(E)-4,4-difluoro-1-(trimethylsilyl)oct-5-en-1-yn-3-one→(E)-4,4-difluorooct-5-en-1-yn-3-ol→(1E,5E)-4,4-difluoro-1-(tributylstannyl)octa-1,5-dien-3-ol→tributyl((1E,5E)-4,4-difluoro-3-((4-methoxybenzyl)oxy)octa-1,5-dien-1-yl)stannane→isopropyl (R,Z)-7-(3-((tert-butyldimethylsilyl)oxy)-5-oxocyclopent-1-en-1-yl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-((1E,5E)-4,4-difluoro-3-((4-methoxybenzyl)oxy)octa-1,5-dien-1-yl)-5-oxocyclopentyl)hept-5-enoate→isopropyl 7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-(4,4-difluoro-3-hydroxyoctyl)-5-oxocyclopentyl)heptanoate→isopropyl 7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoate→7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic acid
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