CAS 1383146-20-0

(R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one

Codes: FEZO-001

Application context (from source-drug indications)

Vasomotor symptomsFezolinetantHot flushesFezolinetantMenopausal symptomsFezolinetantProstate cancerFezolinetantBreast cancerFezolinetantRenal impairmentFezolinetant

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Fezolinetant	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FezolinetantOriginator routesteps: 3total yield: 0.795 g

(R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one→(R)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine→3-methyl-1,2,4-thiadiazole-5-carbohydrazide→(R)-3-methyl-5-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-1,2,4-thiadiazole→4-fluorobenzoyl chloride

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	(R)-4-(2,4-diMethoxybenzyl)-3-Methylpiperazin-2-one Pharmaceutical Intermediates	On request	On request	On request	—

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