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CAS 1392102-38-3
(S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole
Codes: ELBA-023
Application context (from source-drug indications)
Hepatitis CElbasvirChronic hepatitis CElbasvirHepatic function declineElbasvirRenal impairmentElbasvirViral hepatitisElbasvir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Elbasvir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-bromophenol→tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(S)-6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(methoxycarbonyl)-D-valine→2-(2,5-dibromophenyl)acetic acid→3-bromophenyl 2-(2,5-dibromophenyl)acetate→1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one→5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol→((N-((1S,2S)-1,2-diphenyl-2-((3-phenylpropyl)amino)ethyl)-4-methylphenyl)sulfonamido)ruthenium(II) chloride→(R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol→(R)-5-bromo-2-(5-bromoindolin-2-yl)phenol→(6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→di-tert-butyl 2,2'-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-4,2-diyl))(2S,2'S)-bis(pyrrolidine-1-carboxylate)
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