CAS 1392213-15-8

(1-Aminocyclobutyl)methanol hydrogen chloride

Codes: (IXb)805433-1-a,(IXb)805433-1-c

Application context (from source-drug indications)

Idiopathic pulmonary fibrosisNerandomilastInterstitial lung diseaseNerandomilastPulmonary fibrosisNerandomilast肌炎NerandomilastSystemic sclerosisNerandomilast肌病Nerandomilast

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Nerandomilast	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

NerandomilastOptimised routesteps: 8total yield: /

2-Mercaptoacetic acid methyl ester→2-Propenoic acid methyl ester→3-(Methoxycarbonylmethylthio)propionsauremethylester→2-Carbomethoxy-2,3,4,5-tetrahydrothiophen-3-one→Carbamide→3-Ureido-4,5-dihydro-thiophene-2-carboxylic acid methyl ester→6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-diol→2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine→(1-Aminocyclobutyl)methanol tosylate→(1-Aminocyclobutyl)methanol hydrogen chloride→1-Aminocyclobutanecarboxylic acid hydrochloride→[1-[(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)amino]cyclobutyl]methanol→(5R)-2-Chloro-4-[[1-(hydroxymethyl)cyclobutyl]amino]-6,7-dihydro-5H-5lambda4-thieno[3,2-d]pyrimidin-5-one→5-Chloro-2-(piperidin-4-yl)pyrimidine hydrogen chloride→4-Methylbenzene-1-sulfonic acid 5-chloro-2-(piperidin-4-yl)pyrimidine→5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate→4-(5-Chloropyrimidin-2-yl)piperidin-1-ium hexafluoridophosphate(1-)→Piperidine-4-carboximidamide

NerandomilastOptimised routesteps: 3total yield: /

(1-Aminocyclobutyl)methanol hydrogen chloride→5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate→1-((1,1-Dimethylethoxycarbonyl)amino)cyclobutanecarboxylic acid→Methyl 1-(Boc-amino)cyclobutanecarboxylate→1-(Boc-amino)-1-(hydroxymethyl)cyclobutane

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	(1-aminocyclobutyl)methanol hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—

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