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CAS 1393813-40-5
tert-butyl N-propylsulfamoylcarbamate
Codes: MACI-017
Application context (from source-drug indications)
Pulmonary arterial hypertensionMacitentanPulmonary hypertensionMacitentanChronic diseaseMacitentanChronic thromboembolic pulmonary hypertensionMacitentanThromboembolismMacitentanAngina pectorisMacitentan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Macitentan | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-bromophenyl)acetic acid→methyl 2-(4-bromophenyl)acetate→dimethyl carbonate→dimethyl 2-(4-bromophenyl)malonate→formimidamide hydrochloride→5-(4-bromophenyl)pyrimidine-4,6-diol→5-(4-bromophenyl)-4,6-dichloropyrimidine→potassium (N-propylsulfamoyl)amide→MACI-009→ethane-1,2-diol→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→2-methylpropan-2-ol→tert-butyl chlorosulfonylcarbamate→propan-1-amine→tert-butyl N-propylsulfamoylcarbamate→MACI-018
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.