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CAS 1395964-06-3
methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester
Codes: TAFA-005, (V)409139-1-a, (IIIa)409139-8-a, (V)409139-10-a
Application context (from source-drug indications)
Amyloid polyneuropathyTafamidis MeglumineTransthyretin amyloidosisTafamidis MeglumineAmyloidosisTafamidis MeglumineCardiomyopathyTafamidis MeglumineLight-chain (AL) amyloidosisTafamidis MeglumineFamilial amyloid neuropathyTafamidis Meglumine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tafamidis Meglumine | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-3-hydroxybenzoic acid→3,5-dichlorobenzoyl chloride→4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid→2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate
methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate→methyl benzo[d]oxazole-6-carboxylate→(3,5-dichlorophenyl)(mesityl)iodonium trifluoromethanesulfonate
3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol
2-Hydroxy-4-methoxycarbonylaniline→Butyl 4-amino-3-hydroxybenzoate→tert-Butyl 4-amino-3-hydroxybenzoate→Phenyl 4-amino-3-hydroxybenzoate→3,5-Dichlorobenzaldehyde→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→tert-Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→Phenyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate
(4-Carboxy-2-hydroxyphenyl)amine→2-Hydroxy-4-methoxycarbonylaniline→3,5-Dichlorobenzoic acid→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
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