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CAS 13998-27-1
(2R,3R)-2,3-Dihydroxybutanedioic acid 3-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol
Codes: Phenylephrine Hydrochloride-036
Application context (from source-drug indications)
Common coldIbuprofen/Phenylephrine HydrochlorideFeverIbuprofen/Phenylephrine HydrochlorideHeadacheIbuprofen/Phenylephrine HydrochlorideMydriasisPhenylephrine HydrochlorideHypotensionPhenylephrine HydrochlorideCycloplegiaPhenylephrine HydrochlorideSupraventricular tachycardiaPhenylephrine HydrochlorideShockPhenylephrine HydrochlorideIschaemic strokePhenylephrine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibuprofen/Phenylephrine Hydrochloride | Tier C — Watch / trade | - |
| Phenylephrine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ibuprofen/Phenylephrine HydrochlorideOptimised routesteps: 6total yield: 108g(Phenylephrine Hydrochloride (API))
1-(3-Hydroxyphenyl)ethanone→2-Chloro-1-(3-hydroxyphenyl)ethan-1-one→Benzylmethylamine→1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride→3-[1-Hydroxy-2-(methylamino)ethyl]phenol→(2R,3R)-2,3-Dihydroxybutanedioic acid 3-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol→3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol
Phenylephrine HydrochlorideOptimised routesteps: 6total yield: 108g(Phenylephrine Hydrochloride (API))
1-(3-Hydroxyphenyl)ethanone→2-Chloro-1-(3-hydroxyphenyl)ethan-1-one→Benzylmethylamine→1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride→3-[1-Hydroxy-2-(methylamino)ethyl]phenol→(2R,3R)-2,3-Dihydroxybutanedioic acid 3-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol→3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.