CAS 14002-52-9

[1,1'-biphenyl]-2-carbonyl chloride

Codes: CONI-016

Application context (from source-drug indications)

HyponatraemiaConivaptan HydrochlorideAcute decompensated heart failureConivaptan HydrochlorideHeart failureConivaptan HydrochlorideLiver diseaseConivaptan HydrochlorideTraumatic brain injuryConivaptan HydrochlorideKidney diseaseConivaptan Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Conivaptan Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Conivaptan HydrochlorideOptimised routesteps: 6total yield: /

acetimidamide hydrochloride→1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→4-nitrobenzoic acid→(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)(4-nitrophenyl)methanone→(4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)methanone→[1,1'-biphenyl]-2-carbonyl chloride

Conivaptan HydrochlorideOptimised routesteps: 4total yield: /

[1,1'-biphenyl]-2-carboxylic acid→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→[1,1'-biphenyl]-2-carbonyl chloride→4-aminobenzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoyl chloride

Intermediates available on this site

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