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CAS 142757-91-3
(1R,2S,3R,4S)-3-(2-(3-methoxy-3-oxopropyl)benzyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
Codes: IFET-006
Application context (from source-drug indications)
Idiopathic pulmonary fibrosisIfetrobanDuchenne muscular dystrophyIfetroban扩张型心肌病IfetrobanSolid tumourIfetroban阿司匹林引起的哮喘Ifetroban鼻息肉Ifetroban
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ifetroban | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,3aR,4R,7S,7aR)-octahydro-4,7-epoxyisobenzofuran-1-ol→(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)phenyl)magnesium bromide→(S)-(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)phenyl)((1S,2S,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methanol→((1R,2R,3R,4S)-3-(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)benzyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methanol→methyl 3-(2-(((1S,2R,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→(1R,2S,3R,4S)-3-(2-(3-methoxy-3-oxopropyl)benzyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid→(S)-2-amino-3-hydroxy-N-pentylpropanamide→methyl 3-(2-(((1S,2R,3S,4R)-3-(((S)-3-hydroxy-1-oxo-1-(pentylamino)propan-2-yl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→methyl 3-(2-(((1S,2R,3S,4R)-3-((S)-4-(pentylcarbamoyl)-4,5-dihydrooxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→methyl 3-(2-(((1S,2R,3S,4R)-3-(4-(pentylcarbamoyl)oxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate
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