CAS 1429755-58-7

1-(4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea

Codes: IRBIN-007

Application context (from source-drug indications)

Breast cancerTucatinibColorectal cancerTucatinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Tucatinib	Tier C — Watch / trade	2030

Position in synthesis routes (up/downstream chain)

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TucatinibOriginator routesteps: 8total yield: /

2-amino-5-nitrobenzonitrile→(E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide→(E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide→2-amino-2-methylpropan-1-ol→(E)-N'-(2-cyano-4-(3-(1-hydroxy-2-methylpropan-2-yl)thioureido)phenyl)-N,N-dimethylformimidamide→7-(4-(l2-azaneyl)-2-methylphenoxy)-[1,2,4]triazolo[1,5-a]pyridine→1-(4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea→4-(2-methyl-4-nitrophenoxy)pyridin-2-amine→(E)-N,N-dimethyl-N'-(4-(2-methyl-4-nitrophenoxy)pyridin-2-yl)formimidamide→7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a]pyridine→N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-y Pharmaceutical Intermediates	On request	On request	On request	—

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