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CAS 143957-14-6
((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
Codes: LAMI-012
Application context (from source-drug indications)
HIV infectionDolutegravir/Lamivudine/Tenofovir AlafenamideHIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHepatitis BLamivudineChronic hepatitis BLamivudineHIV infectionLamivudineRett syndromeLamivudineAlzheimer's diseaseLamivudineRetinal detachmentLamivudine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dolutegravir/Lamivudine/Tenofovir Alafenamide | Tier C — Watch / trade | - |
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Lamivudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate→1,4-dithiane-2,5-diol→N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide→((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate→1,4-dithiane-2,5-diol→N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide→((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate→1,4-dithiane-2,5-diol→N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide→((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
2-oxoethyl benzoate→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate→1,4-dithiane-2,5-diol→N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide→((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
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