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CAS 144809-28-9
(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Codes: PIOG-013
Application context (from source-drug indications)
Type 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Alogliptin Benzoate/Pioglitazone Hydrochloride | Tier C — Watch / trade | - |
| Pioglitazone Hydrochloride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-fluorobenzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione→2-(5-ethylpyridin-2-yl)ethyl methanesulfonate→4-hydroxybenzaldehyde
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-fluorobenzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione→2-(5-ethylpyridin-2-yl)ethyl methanesulfonate→4-hydroxybenzaldehyde
Intermediates available on this site
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