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CAS 144810-01-5
(1,4-dioxaspiro[4.5]dec-7-en-8-yloxy)trimethylsilane
Codes: DEXP-002
Application context (from source-drug indications)
肺嗜酸粒细胞增多Dexpramipexole DihydrochlorideAsthmaDexpramipexole DihydrochlorideChronic obstructive pulmonary diseaseDexpramipexole Dihydrochloride高嗜酸性粒细胞综合征Dexpramipexole DihydrochlorideAmyotrophic lateral sclerosisDexpramipexole Dihydrochloride嗜酸粒细胞性哮喘Dexpramipexole Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dexpramipexole Dihydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4-dioxaspiro[4.5]decan-8-one→(1,4-dioxaspiro[4.5]dec-7-en-8-yloxy)trimethylsilane→5,7-dihydro-4H-spiro[benzo[d]thiazole-6,2'-[1,3]dioxolan]-2-amine→2-amino-4,5-dihydrobenzo[d]thiazol-6(7H)-one→N-(6-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl benzoate→(S)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl 4-methylbenzenesulfonate→(R)-N-(6-azido-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→propyl 4-methylbenzenesulfonate
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