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CAS 1451008-28-8
6-amino-4-chloroquinazolin-7-ol
Codes: AFAT-023
Application context (from source-drug indications)
Non-small cell lung cancerAfatinib DimaleateHead and neck squamous cell carcinomaAfatinib DimaleateHead and neck cancerAfatinib DimaleateChordomaAfatinib DimaleateSquamous cell carcinomaAfatinib DimaleateGallbladder cancerAfatinib Dimaleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Afatinib Dimaleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→methyl 3-amino-4-hydroxybenzoate→methyl 5-amino-4-hydroxy-2-nitrobenzoate→methyl 2,5-diamino-4-hydroxybenzoate→6-amino-7-hydroxyquinazolin-4(3H)-one→6-amino-4-chloroquinazolin-7-ol→(S)-4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-amine→(E)-4-(dimethylamino)but-2-enoyl chloride→(S,E)-N-(4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Intermediates available on this site
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