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CAS 1451207-76-3
tert-butyl (4-chloro-3-iodophenyl)carbamate
Codes: VISM-011
Application context (from source-drug indications)
Basal cell carcinomaVismodegibMultiple myelomaVismodegibLymphomaVismodegibSolid tumourVismodegibHaematological malignancyVismodegibMesenchymal chondrosarcomaVismodegib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vismodegib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-chloro-4-(methylsulfonyl)benzoyl chloride→4-chlorobenzoic acid→4-chloro-3-iodobenzoic acid→tert-butyl (4-chloro-3-iodophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→2-bromopyridine→tert-butyl (4-chloro-3-(pyridin-2-yl)phenyl)carbamate→4-chloro-3-(pyridin-2-yl)aniline
Intermediates available on this site
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