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CAS 145514-62-1
(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
Codes: (XI)101438-66-a, (II)140605-19-a, (III)140605-30-a
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateBladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Pancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelNon-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diol→2,2,2-Trichloroacetonitrile→(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diyl bis(2,2,2-trichloroethanimidate)→(4S,5R)-5-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-4-phenyl-2-(trichloromethyl)-4,5-dihydro-1,3-oxazole→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid→N-((1S,2R)-3-TBDMSoxy-2-hydroxy-1-phenylpropyl)-2,2,2-trichloroacetamide→(2R,3S)-3-Amino-3-phenylpropane-1,2-diol→alpha-Chlorobenzaldehyde→N-[(1S,2R)-2,3-Dihydroxy-1-phenylpropyl]benzamide→(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
2-(2-Nitrophenyl)acetic acid→(2-Nitrophenyl)acetyl chloride→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoic acid→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-1,13-dihydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-13-([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoyl]oxy)-1-hydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate
(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diol→2,2,2-Trichloroacetonitrile→(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diyl bis(2,2,2-trichloroethanimidate)→(4S,5R)-5-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-4-phenyl-2-(trichloromethyl)-4,5-dihydro-1,3-oxazole→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid→N-((1S,2R)-3-TBDMSoxy-2-hydroxy-1-phenylpropyl)-2,2,2-trichloroacetamide→(2R,3S)-3-Amino-3-phenylpropane-1,2-diol→alpha-Chlorobenzaldehyde→N-[(1S,2R)-2,3-Dihydroxy-1-phenylpropyl]benzamide→(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
2-(2-Nitrophenyl)acetic acid→(2-Nitrophenyl)acetyl chloride→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoic acid→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-1,13-dihydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-13-([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-(2-nitrophenyl)acetoxy]-3-phenylpropanoyl]oxy)-1-hydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate
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