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CAS 1455358-14-1
(S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
Codes: MK-8031-046
Application context (from source-drug indications)
MigraineAtogepant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atogepant | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,3-dibromo-5-chloropyridine→(2-bromo-5-chloropyridin-3-yl)methanol→5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)picolinaldehyde→1-(tert-butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one→(E)-1-(tert-butyl)-3-((5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one→1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one→1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one→(1S,2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methylquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium→(S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one→(S)-1'-(tert-butyl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid→(S)-(6-methylquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol→1-bromo-2-(bromomethyl)-4-methoxybenzene
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one Pharmaceutical Intermediates | On request | On request | On request | — |
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