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CAS 145978-32-1
(Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate
Codes: Tenofovir disoproxil phosphate-031
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 3total yield: 21.8g(Tenofovir disoproxil phosphate-009)
Diethyl phosphonate→Diethyl phosphonomethanol→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(Diethoxyphosphoryl)methyl methanesulfonate→(Diethoxyphosphoryl)methyl 4-fluorobenzene-1-sulfonate→(Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 3total yield: 21.8g(Tenofovir disoproxil phosphate-009)
Diethyl phosphonate→Diethyl phosphonomethanol→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(Diethoxyphosphoryl)methyl methanesulfonate→(Diethoxyphosphoryl)methyl 4-fluorobenzene-1-sulfonate→(Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 3total yield: 21.8g(Tenofovir disoproxil phosphate-009)
Diethyl phosphonate→Diethyl phosphonomethanol→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(Diethoxyphosphoryl)methyl methanesulfonate→(Diethoxyphosphoryl)methyl 4-fluorobenzene-1-sulfonate→(Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate
Tenofovir disoproxil phosphateOptimised routesteps: 3total yield: 21.8g(Tenofovir disoproxil phosphate-009)
Diethyl phosphonate→Diethyl phosphonomethanol→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(Diethoxyphosphoryl)methyl methanesulfonate→(Diethoxyphosphoryl)methyl 4-fluorobenzene-1-sulfonate→(Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.