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CAS 146464-90-6
methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate
Codes: PRAL-003
Application context (from source-drug indications)
Peripheral T-cell lymphomaPralatrexateT-cell lymphomaPralatrexateSolid tumourPralatrexateHaematological malignancyPralatrexateB-cell lymphomaPralatrexateCutaneous T-cell lymphomaPralatrexate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pralatrexate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→(S)-diethyl 2-aminopentanedioate hydrochloride→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate hydrobromide→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→sodium 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate→(S)-diethyl 2-aminopentanedioate
Intermediates available on this site
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