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CAS 146924-94-9
(+)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one(3R,4S)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one
Codes: (VIII)101438-70-a, (I)140605-34-a
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateBladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Pancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelNon-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Benzaldehyde→1-Amino-4-methoxybenzene→(NZ)-4-Methoxy-N-(phenylmethylidene)aniline→(2-Chloranyl-2-oxidanylideneethyl) ethanoate→(3R,4S)-1-(4-Methoxyphenyl)-4-phenyl-3-[[tri(propan-2-yl)silyl]oxy]azetidin-2-one→1-(4-Methoxyphenyl)-2-oxo-4-phenylazetidin-3-yl acetate→3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→1-(4-Methoxyphenyl)-4-phenylazetidine-2,3-dione→(+)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(3R,4S)-4-Phenyl-3-{[tris(propan-2-yl)silyl]oxy}azetidin-2-one→alpha-Chlorobenzaldehyde→(3R,4S)-1-Benzoyl-4-phenyl-3-[[tri(propan-2-yl)silyl]oxy]azetidin-2-one
(3R,4S)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(Pentane-1,5-diyl)bis[chlorodi(propan-2-yl)silane]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis[1-(4-methoxyphenyl)-4-phenylazetidin-2-one]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(4-phenylazetidin-2-one)→Di-tert-butyl (3R,4S,3'R,4'S)-3,3'-(pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(2-oxo-4-phenylazetidine-1-carboxylate)
Benzaldehyde→1-Amino-4-methoxybenzene→(NZ)-4-Methoxy-N-(phenylmethylidene)aniline→(2-Chloranyl-2-oxidanylideneethyl) ethanoate→(3R,4S)-1-(4-Methoxyphenyl)-4-phenyl-3-[[tri(propan-2-yl)silyl]oxy]azetidin-2-one→1-(4-Methoxyphenyl)-2-oxo-4-phenylazetidin-3-yl acetate→3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→1-(4-Methoxyphenyl)-4-phenylazetidine-2,3-dione→(+)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(3R,4S)-4-Phenyl-3-{[tris(propan-2-yl)silyl]oxy}azetidin-2-one→alpha-Chlorobenzaldehyde→(3R,4S)-1-Benzoyl-4-phenyl-3-[[tri(propan-2-yl)silyl]oxy]azetidin-2-one
(3R,4S)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(Pentane-1,5-diyl)bis[chlorodi(propan-2-yl)silane]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis[1-(4-methoxyphenyl)-4-phenylazetidin-2-one]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(4-phenylazetidin-2-one)→Di-tert-butyl (3R,4S,3'R,4'S)-3,3'-(pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(2-oxo-4-phenylazetidine-1-carboxylate)
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