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CAS 1492978-64-9
(2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol
Codes: Tenofovir disoproxil phosphate-019
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: 1.7g(Tenofovir disoproxil phosphate-014)
(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→6-Chloro-5-nitropyrimidin-4-amine→(2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol→4,6-Dichloro-5-nitropyrimidine→(2R)-1-Aminopropan-2-ol→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: 1.7g(Tenofovir disoproxil phosphate-014)
(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→6-Chloro-5-nitropyrimidin-4-amine→(2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol→4,6-Dichloro-5-nitropyrimidine→(2R)-1-Aminopropan-2-ol→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: 1.7g(Tenofovir disoproxil phosphate-014)
(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→6-Chloro-5-nitropyrimidin-4-amine→(2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol→4,6-Dichloro-5-nitropyrimidine→(2R)-1-Aminopropan-2-ol→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol
Tenofovir disoproxil phosphateOptimised routesteps: 4total yield: 1.7g(Tenofovir disoproxil phosphate-014)
(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→6-Chloro-5-nitropyrimidin-4-amine→(2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol→4,6-Dichloro-5-nitropyrimidine→(2R)-1-Aminopropan-2-ol→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol
Intermediates available on this site
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