CAS 150-13-0

4-Aminobenzoic acid4-aminobenzoic acid

Codes: Tetracaine-022, CONI-017

Application context (from source-drug indications)

AnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideHyponatraemiaConivaptan HydrochlorideAcute decompensated heart failureConivaptan HydrochlorideHeart failureConivaptan HydrochlorideLiver diseaseConivaptan HydrochlorideTraumatic brain injuryConivaptan HydrochlorideKidney diseaseConivaptan HydrochlorideAnaesthesiaTetracaine HydrochlorideRetinitis pigmentosaTetracaine HydrochloridePainTetracaine Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C — Watch / trade	-
Conivaptan Hydrochloride	Tier C — Watch / trade	-
Tetracaine Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 3total yield: 93.5g(Tetracaine)

4-Aminobenzoic acid→Butanal→N,N-Dimethyl-2-hydroxyethylamine

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 5total yield: /

4-Bromobenzoyl chloride→2-(Dimethylamino)ethyl 4-bromobenzoate→Ethyl 4-aminobenzoate→n-Butyl bromide→N,N-Dimethylaminoethanol→Monobutylamine→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid ethyl ester→4-Aminobenzoic acid

Conivaptan HydrochlorideOptimised routesteps: 4total yield: /

[1,1'-biphenyl]-2-carboxylic acid→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→[1,1'-biphenyl]-2-carbonyl chloride→4-aminobenzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoyl chloride

Conivaptan HydrochlorideOptimised routesteps: 5total yield: /

[1,1'-biphenyl]-2-carboxylic acid→acetimidamide hydrochloride→1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→4-aminobenzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoic acid→pyridine hydrobromide→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine hydrate

Tetracaine HydrochlorideOptimised routesteps: 3total yield: 93.5g(Tetracaine)

4-Aminobenzoic acid→Butanal→N,N-Dimethyl-2-hydroxyethylamine

Tetracaine HydrochlorideOptimised routesteps: 5total yield: /

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