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CAS 150058-27-8
methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
Codes: AZILS-011, AZILS-022a, AZIL-027
Application context (from source-drug indications)
HypertensionAzilsartanEssential hypertensionAzilsartanType 2 diabetesAzilsartanObesityAzilsartanDiabetesAzilsartanHypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneEssential hypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneEssential hypertensionAzilsartan Medoxomil PotassiumHypertensionAzilsartan Medoxomil Potassium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Azilsartan | Tier C — Watch / trade | - |
| Azilsartan Medoxomil Potassium/Chlorthalidone | Tier C — Watch / trade | - |
| Azilsartan Medoxomil Potassium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→methyl 2-ethoxy-1-((2'-formyl-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (E)-2-ethoxy-1-((2'-((hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (Z)-1-((2'-(chloro(hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→methyl 2,3-diaminobenzoate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
4'-methyl-[1,1'-biphenyl]-2-carbonitrile→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-1,2,4-oxadiazol-5(4H)-one→3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1,2,4-oxadiazol-5(4H)-one→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine→ethyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine→ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine
4'-methyl-[1,1'-biphenyl]-2-carbonitrile→N'-hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine
4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→N'-hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide hydrochloride→N'-((ethoxycarbonyl)oxy)-4'-methyl-[1,1'-biphenyl]-2-carboximidamide→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-1,2,4-oxadiazol-5(4H)-one→tert-butyl 3-(4'-methyl-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→tert-butyl 3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→tert-butyl 3-(4'-((2-ethoxy-7-(methoxycarbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→1-((2'-(4-(tert-butoxycarbonyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid→tert-butyl 3-(4'-((2-ethoxy-7-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate
4'-methyl-[1,1'-biphenyl]-2-carbonitrile→N'-hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine
4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→N'-hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide hydrochloride→N'-((ethoxycarbonyl)oxy)-4'-methyl-[1,1'-biphenyl]-2-carboximidamide→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-1,2,4-oxadiazol-5(4H)-one→tert-butyl 3-(4'-methyl-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→tert-butyl 3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→tert-butyl 3-(4'-((2-ethoxy-7-(methoxycarbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate→1-((2'-(4-(tert-butoxycarbonyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid→tert-butyl 3-(4'-((2-ethoxy-7-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-1,2,4-oxadiazole-4(5H)-carboxylate
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