CAS 153-94-6

D-tryptophan

Codes: TADA-016

Application context (from source-drug indications)

Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinErectile dysfunctionAmlodipine Besylate/TadalafilHypertensionAmlodipine Besylate/TadalafilBenign prostatic hyperplasiaTadalafilPulmonary hypertensionTadalafilPulmonary arterial hypertensionTadalafilErectile dysfunctionTadalafilPremature ejaculationTadalafilGenitourinary neoplasmTadalafil

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Tadalafil/Tamsulosin	Tier C — Watch / trade	-
Amlodipine Besylate/Tadalafil	Tier C — Watch / trade	-
Tadalafil	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Tadalafil/TamsulosinOptimised routesteps: 1total yield: /

benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan

Amlodipine Besylate/TadalafilOptimised routesteps: 1total yield: /

benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan

TadalafilOptimised routesteps: 1total yield: /

benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan

Intermediates available on this site

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