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CAS 154026-93-4
tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
Codes: Atorvastatin-166
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 6total yield: 206.7g(Atorvastatin-161)
Methyl (3S)-4-chloro-3-hydroxybutanoate→Methyl (3S)-4-chloro-3-[(trimethylsilyl)oxy]butanoate→(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanal→tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate→tert-Butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→[(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate→1,1-Dimethylethyl acetate→1-Methoxy-1-methylethyl methyl ether
Methyl (3S)-4-chloro-3-hydroxybutanoate→Methyl (3S)-4-chloro-3-[(trimethylsilyl)oxy]butanoate→(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanal→tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate→tert-Butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→[(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate→1,1-Dimethylethyl acetate→1-Methoxy-1-methylethyl methyl ether
Intermediates available on this site
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