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CAS 154542-77-5

4'-(bromomethyl)-2-iodo-1,1'-biphenyl

Codes: TELM-035

Application context (from source-drug indications)

HypertensionTelmisartan/Amlodipine Besylate/HydrochlorothiazideHypertensionRosuvastatin Calcium/TelmisartanHyperlipidaemiaRosuvastatin Calcium/TelmisartanHypertensionAmlodipine Besylate/TelmisartanHypertensionTelmisartanBreast cancerTelmisartanCardiomyopathyTelmisartanAlzheimer's diseaseTelmisartanRisk-reduction measureTelmisartanMyocardial infarctionTelmisartan

Source drugs (routes using this intermediate)

DrugTierExpiry
Telmisartan/Amlodipine Besylate/HydrochlorothiazideTier C — Watch / trade-
Rosuvastatin Calcium/TelmisartanTier C — Watch / trade-
Amlodipine Besylate/TelmisartanTier C — Watch / trade-
TelmisartanTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Telmisartan/Amlodipine Besylate/HydrochlorothiazideOptimised routesteps: 4total yield: /
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→1-bromo-4-methylbenzene→1-bromo-2-chlorobenzene→2-iodo-4'-methyl-1,1'-biphenyl→4'-(bromomethyl)-2-iodo-1,1'-biphenyl→3'-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
Rosuvastatin Calcium/TelmisartanOptimised routesteps: 4total yield: /
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→1-bromo-4-methylbenzene→1-bromo-2-chlorobenzene→2-iodo-4'-methyl-1,1'-biphenyl→4'-(bromomethyl)-2-iodo-1,1'-biphenyl→3'-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
Amlodipine Besylate/TelmisartanOptimised routesteps: 4total yield: /
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→1-bromo-4-methylbenzene→1-bromo-2-chlorobenzene→2-iodo-4'-methyl-1,1'-biphenyl→4'-(bromomethyl)-2-iodo-1,1'-biphenyl→3'-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
TelmisartanOptimised routesteps: 4total yield: /
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→1-bromo-4-methylbenzene→1-bromo-2-chlorobenzene→2-iodo-4'-methyl-1,1'-biphenyl→4'-(bromomethyl)-2-iodo-1,1'-biphenyl→3'-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

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