← Back to patent-cliff list
CAS 1574506-72-1
(R)-1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
Codes: IBRT-014, (VI)461018-3-a, (III)461018-29-a
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→4-phenoxybenzoyl chloride→(R)-1-(3-hydrazinylpiperidin-1-yl)prop-2-en-1-one→(R)-1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→(4-Phenoxybenzoyl)malononitrile→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Dimethylamino)formaldehyde dimethyl acetal
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→Amide c1
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.