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CAS 158938-08-0
4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid4''-(Pentyloxy)-1,1':4',1''-terphenyl-4-carboxylic acid
Codes: ANID-004, (XXII)796686-1-c
Application context (from source-drug indications)
CandidiasisAnidulafunginCandidaemiaAnidulafunginFungal infectionAnidulafunginPeritonitisAnidulafunginAbscessAnidulafunginRespiratory tract infectionAnidulafungin侵袭性念珠菌病Rezafungin acetateCandidiasisRezafungin acetateCandidaemiaRezafungin acetate卡氏肺囊虫感染Rezafungin acetate侵袭性真菌感染Rezafungin acetateAspergillus infectionRezafungin acetate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Anidulafungin | Tier C — Watch / trade | - |
| Rezafungin acetate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromo-4'-(pentyloxy)-1,1'-biphenyl→methyl 4-iodobenzoate→methyl 4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylate→4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid→2,4,5-trichlorophenol→2,4,5-trichlorophenyl 4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylate→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-amino-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6,20-bis((R)-1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexaone
2-(4-(pentyloxy)phenyl)-1,3,2-dioxaborolane→4'-iodo-[1,1'-biphenyl]-4-carboxylic acid→4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid→(1H-benzo[d][1,2,3]triazol-1-yl)(4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-yl)methanone→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-amino-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6,20-bis((R)-1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexaone
4(R),5(R)-Dihydroxy-N2-[1-oxo-9(Z),12(Z)-octadecadienyl]-L-ornithyl-L-threonyl-4(R)-hydroxy-L-prolyl-4(S)-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-L-threonyl-3(S)-hydroxy-4(S)-methyl-L-proline N-6.1-C-1.6-lactam→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[1(R)-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid 2,4,5-trichlorophenyl ester→4'-Bromobiphenyl-4-yl pentyl ether→2,4,5-Trichlorophenol→4'-(Pentyloxy)biphenyl-4-ylboronic acid→Methyl 4-iodobenzoate→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid methyl ester→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid
2-[4-Pentyloxyphenyl]-1,3,2-dioxaborolane→4-(4-Iodophenyl)benzoic acid→1H-1,2,3-Benzotriazol-1-ol→1-(4''-(Pentyloxy)-p-terphenyl-4-ylcarbonyloxy)-1H-benzotriazole→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[1(R)-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone→4'-(Pentyloxy)biphenyl-4-ylboronic acid→Methyl 4-iodobenzoate→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid
1,4-Dibromobenzene→1,4-Phenylenediboronic acidd→4-Bromophenyl pentyl ether→Ethyl 4-iodobenzoate→4-Bromobenzoic acid ethyl ester→Ethyl 4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxylate→4-Ethoxycarbonylphenylmagnesium bromide→4-Bromophenyl tosylate→Ethyl 4'-[(4-methylbenzene-1-sulfonyl)oxy][1,1'-biphenyl]-4-carboxylate→4-Pentoxyphenylmagnesium bromide→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid
4,6-Dimethoxy-1,3,5-triazin-2-yl 3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxylate→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone hydrogen chloride→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[1(R)-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid
4-Iodobenzoic acid→Cyclic bis(tetramethylethylene) ester p-Benzenediboronic acid→1-Iodo-4-(pentyloxy)benzene→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid
(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-9-amino-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→(11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide
(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-9-amino-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→4''-(Pentyloxy)-1,1':4',1''-terphenyl-4-carboxylic acid→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→(11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4'-Pentoxy-4-biphenylyl)benzoic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4''-(Pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — |
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