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CAS 160844-75-7
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Codes: FEBU-008
Application context (from source-drug indications)
HyperuricaemiaFebuxostatGoutFebuxostatIntracranial haemorrhageFebuxostatUlcerative colitisFebuxostatChronic renal impairmentFebuxostatPainFebuxostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Febuxostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-hydroxy-3-nitrobenzaldehyde→4-hydroxy-3-nitrobenzonitrile→4-hydroxy-3-nitrobenzothioamide→ethyl 2-chloro-3-oxobutanoate→ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→1-bromo-2-methylpropane→ethyl 2-(4-isobutoxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
ethyl 2-chloro-3-oxobutanoate→1-bromo-2-methylpropane→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→5-bromo-2-hydroxybenzaldehyde→5-bromo-2-isobutoxybenzaldehyde→5-bromo-2-isobutoxybenzonitrile→(3-cyano-4-isobutoxyphenyl)boronic acid→ethyl 2-bromo-4-methylthiazole-5-carboxylate→thiourea→ethyl 2-amino-4-methylthiazole-5-carboxylate
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→4-hydroxybenzaldehyde→4-isobutoxybenzaldehyde→3-bromo-4-isobutoxybenzaldehyde→(E)-3-bromo-4-isobutoxybenzaldehyde oxime→3-bromo-4-isobutoxybenzonitrile→3-bromo-4-isobutoxybenzothioamide→ethyl 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→ethyl 2-chloro-3-oxobutanoate→1-bromo-2-methylpropane
ethyl 2-chloro-3-oxobutanoate→1-bromo-2-methylpropane→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→2,4-dibromophenol→2,4-dibromo-1-isobutoxybenzene→4-isobutoxyisophthalonitrile→3-cyano-4-isobutoxybenzothioamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.