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CAS 1623-95-6
4-phenoxybenzoyl chloride4-Phenoxybenzoyl chloride
Codes: IBRT-012, (I)461018-3-a, (VI)461018-25-a, ZANU-002
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibWaldenström macroglobulinaemiaZanubrutinibChronic lymphocytic leukaemiaZanubrutinibFollicular lymphomaZanubrutinibMarginal zone B-cell lymphomaZanubrutinibMantle cell lymphomaZanubrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
| Zanubrutinib | Tier A — Act now | 2031 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→(4-Phenoxybenzoyl)malononitrile→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Dimethylamino)formaldehyde dimethyl acetal
(3R)-3-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)(nitroso)amino]piperidine-1-carboxylate→tert-Butyl (3R)-3-[1-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate→(3R)-3-Hydrazinylpiperidine→Amide c1→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→5-Amino-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carbonitrile→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbaldehyde→2-Propenoyl chloride→3-Aminopiperidine→5-Oxo-D-proline (3R)-piperidin-3-amine→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate
4-phenoxybenzoic acid→4-phenoxybenzoyl chloride→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Z)-tert-butyl 4-(3-(dimethylamino)acryloyl)piperidine-1-carboxylate→tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→tert-butyl 4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2,2,2-trifluoroacetate→7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide→(S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
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