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CAS 163451-81-8
(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
Codes: Teriflunomide
Application context (from source-drug indications)
Systemic lupus erythematosusTeriflunomide Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Teriflunomide Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 3-oxobutanoate→ethyl (Z)-2-(ethoxymethylene)-3-oxobutanoate→ethyl 5-methylisoxazole-4-carboxylate→5-methylisoxazole-4-carboxylic acid→5-methylisoxazole-4-carbonyl chloride→4-(trifluoromethyl)aniline→5-methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
2-cyanoacetic acid→4-(trifluoromethyl)aniline→2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
ethyl 3-oxobutanoate→4-(trifluoromethyl)aniline→3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide→2-bromo-3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
ethyl 2-cyanoacetate→ethyl (Z)-2-cyano-3-hydroxybut-2-enoate→4-(trifluoromethyl)aniline→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
4-(trifluoromethyl)benzoic acid→4-(trifluoromethyl)benzoyl azide→1-isocyanato-4-(trifluoromethyl)benzene→3-oxobutanenitrile→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
5-methylisoxazole-4-carboxylic acid→5-methylisoxazole-4-carbonyl chloride→4-(trifluoromethyl)aniline→5-methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide→(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.