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CAS 1642601-01-1
1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one
Codes: (IV)461018-14-a, (XI)461018-20-a, (II)461018-29-a
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(3S)-Piperidin-3-ol--hydrogen chloride (1→(3S)-1-Benzylpiperidin-3-ol→(3S)-1-Benzylpiperidin-3-yl methanesulfonate→2-Propenoic acid→(3S)-Piperidin-3-yl methanesulfonate→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3R)-1-Benzylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→(3S)-1-(Prop-2-enoyl)piperidin-3-yl methanesulfonate
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→Amide c1
Intermediates available on this site
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