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CAS 1644180-14-2
(2S,3S)-N-cyclopropyl-3-propyloxirane-2-carboxamide
Codes: TELAP-022
Application context (from source-drug indications)
Hepatitis CTelaprevirChronic hepatitis CTelaprevirHIV infectionTelaprevirHepatic function declineTelaprevirOpioid dependenceTelaprevirKidney diseaseTelaprevir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Telaprevir | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid→(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide→(E)-hex-2-en-1-ol→((2R,3S)-3-propyloxiran-2-yl)methanol→(2S,3S)-3-propyloxirane-2-carboxylic acid→cyclopropanamine→(2S,3S)-N-cyclopropyl-3-propyloxirane-2-carboxamide→(2S,3S)-3-azido-N-cyclopropyl-2-hydroxyhexanamide→(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride→(1S,3aR,6aS)-2-benzyloctahydrocyclopenta[c]pyrrole-1-carboxylic acid→(1S,3aR,6aS)-2-benzyl-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide→(1S,3aR,6aS)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
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