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CAS 1644441-68-8
(Z)-methyl 4-(3-methoxy-1-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)-3-oxo-1-phenylprop-1-en-2-yl)-3-nitrobenzoate
Codes: NINT-025
Application context (from source-drug indications)
Systemic sclerosis-associated interstitial lung diseaseNintedanib EsylateIdiopathic pulmonary fibrosisNintedanib EsylateNon-small cell lung cancerNintedanib EsylatePulmonary fibrosisNintedanib EsylateInterstitial lung diseaseNintedanib EsylateHereditary haemorrhagic telangiectasiaNintedanib Esylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Nintedanib Esylate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate→(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→(Z)-methyl 4-(1,3-dimethoxy-3-oxo-1-phenylprop-1-en-2-yl)-3-nitrobenzoate→(Z)-methyl 4-(3-methoxy-1-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)-3-oxo-1-phenylprop-1-en-2-yl)-3-nitrobenzoate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.