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CAS 16450-41-2
(S)-diethyl 2-aminopentanedioate(S)-Glutamic acid diethyl ester
Codes: PRAL-034, Folic Acid-083, PEME-026
Application context (from source-drug indications)
Peripheral T-cell lymphomaPralatrexateT-cell lymphomaPralatrexateSolid tumourPralatrexateHaematological malignancyPralatrexateB-cell lymphomaPralatrexateCutaneous T-cell lymphomaPralatrexateEssential hypertensionEnalapril Maleate/Folic AcidMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic AcidNon-small cell lung cancerPemetrexed Disodium Hydrate间皮组织肿瘤Pemetrexed Disodium Hydrate胸膜孤立性纤维瘤Pemetrexed Disodium HydrateBladder cancerPemetrexed Disodium HydrateUrothelial carcinomaPemetrexed Disodium HydrateSolid tumourPemetrexed Disodium Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pralatrexate | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Folic Acid | Tier C — Watch / trade | - |
| Pemetrexed Disodium Hydrate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate hydrobromide→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→sodium 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate→(S)-diethyl 2-aminopentanedioate
4-(Ethoxycarbonyl)aniline→(+/-)-2-(Chloromethyl)oxirane→Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate→2,4,5-Triamino-6-hydroxypyrimidine sulfate→Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate→4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid→(S)-Glutamic acid diethyl ester→Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate
4-(Ethoxycarbonyl)aniline→(+/-)-2-(Chloromethyl)oxirane→Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate→2,4,5-Triamino-6-hydroxypyrimidine sulfate→Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate→4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid→(S)-Glutamic acid diethyl ester→Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate
dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate→4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid→ethyl 4-(3-oxopropyl)benzoate→3-ethylbenzo[d]thiazol-3-ium bromide→ethyl 4-(4-hydroxy-3-oxobutyl)benzoate→malononitrile→ethyl 4-(2-(5-amino-4-cyanofuran-3-yl)ethyl)benzoate→guanidine→ethyl 4-(2-(2,4-diamino-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate→(S)-diethyl 2-aminopentanedioate
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