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CAS 1664338-79-7
P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide
Codes: Tenofovir disoproxil phosphate-042
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Propane-1,2(R)-diol→(4R)-4-Methyl-1,3-dioxolane→N,N,N',N'-Tetraethylphosphorodiamidous chloride→P-([[(2R)-1-Chloropropan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide→6-Aminopurine→P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide
Propane-1,2(R)-diol→(4R)-4-Methyl-1,3-dioxolane→N,N,N',N'-Tetraethylphosphorodiamidous chloride→P-([[(2R)-1-Chloropropan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide→6-Aminopurine→P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: /
Propane-1,2(R)-diol→(4R)-4-Methyl-1,3-dioxolane→N,N,N',N'-Tetraethylphosphorodiamidous chloride→P-([[(2R)-1-Chloropropan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide→6-Aminopurine→P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide
Propane-1,2(R)-diol→(4R)-4-Methyl-1,3-dioxolane→N,N,N',N'-Tetraethylphosphorodiamidous chloride→P-([[(2R)-1-Chloropropan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide→6-Aminopurine→P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide
Intermediates available on this site
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