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CAS 1672665-59-6
3-((2,2-difluoro-7-(methylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Codes: PT-2385-013
Application context (from source-drug indications)
von Hippel-Lindau syndromePT-2385SarcomaPT-2385Renal cell carcinomaPT-2385肾肿瘤PT-2385GlioblastomaPT-2385
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| PT-2385 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(methylthio)phenol→2-hydroxy-5-(methylthio)benzaldehyde→2,2-dimethyl-1,3-dioxane-4,6-dione→6-(methylthio)-2-oxo-2H-chromene-3-carboxylic acid→3-(2-hydroxy-5-(methylthio)phenyl)propanoic acid→3,5-difluorobenzonitrile→3-(2-(3-cyano-5-fluorophenoxy)-5-(methylthio)phenyl)propanoic acid→3-(2-(3-cyano-5-fluorophenoxy)-5-(methylthio)phenyl)propanoyl chloride→3-fluoro-5-((7-(methylthio)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile→3-fluoro-5-((7-(methylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile→3-methoxypropan-1-amine→(E)-3-fluoro-5-((1-((3-methoxypropyl)imino)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile→3-((2,2-difluoro-7-(methylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
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