CAS 1681-37-4

3-nitropyridin-4-amine

Codes: AMIF-004

Application context (from source-drug indications)

Lambert-Eaton myasthenic syndromeAmifampridine PhosphateSpinal muscular atrophyAmifampridine PhosphateMyasthenia gravisAmifampridine PhosphatePaediatric spinal muscular atrophyAmifampridine PhosphateCongenital myasthenic syndromeAmifampridine PhosphateMultiple sclerosisAmifampridine Phosphate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Amifampridine Phosphate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Amifampridine PhosphateOriginator routesteps: 5total yield: /

pyridin-4-ol→3-nitropyridin-4-ol→4-ethoxy-3-nitropyridine hydrochloride→3-nitropyridin-4-amine

Amifampridine PhosphateOptimised routesteps: 4total yield: 535 mg

3-nitropyridin-4-amine→pyridin-4-amine→N-(3-nitropyridin-4-yl)acetamide→N-(pyridin-4-yl)acetamide

Intermediates available on this site

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