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CAS 170908-81-3
2,2',2''-(10-[2-[(2,5-Dioxopyrrolidin-1-yl)oxy]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
Codes: Lutetium (177Lu) vipivotide tetraxetan-017
Application context (from source-drug indications)
Hormone-sensitive prostate cancerLutetium (177Lu) vipivotide tetraxetanCastration-resistant prostate cancerLutetium (177Lu) vipivotide tetraxetanProstate cancerLutetium (177Lu) vipivotide tetraxetanLiver cancerLutetium (177Lu) vipivotide tetraxetanHepatocellular carcinomaLutetium (177Lu) vipivotide tetraxetanRenal cell carcinomaLutetium (177Lu) vipivotide tetraxetan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Resin bound (2S)-6-[[(2S)-2-[[(1r,4S)-4-(aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid→(3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid→(2S)-6-[[(2S)-2-[[(1r,4S)-4-(Aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid→2,2',2''-(10-[2-[(2,5-Dioxopyrrolidin-1-yl)oxy]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid→(2S)-2-([[(2S)-1,5-Di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)-6-[[(2S)-3-(naphthalen-2-yl)-2-[[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexane-1-carbonyl]amino]propanoyl]amino]hexanoic acid
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