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CAS 1713286-23-7
tert-butyl (S)-2-(5-bromo-4-chloro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
Codes: ELBA-027
Application context (from source-drug indications)
Hepatitis CElbasvirChronic hepatitis CElbasvirHepatic function declineElbasvirRenal impairmentElbasvirViral hepatitisElbasvir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Elbasvir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(methoxycarbonyl)-D-valine→tert-butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(5-bromo-4-chloro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(4-chloro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(S)-4-chloro-2-(pyrrolidin-2-yl)-1H-imidazole→methyl ((R)-1-((S)-2-(4-chloro-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate→(S)-6-phenyl-3,10-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole
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