CAS 172015-99-5

(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide

Codes: LEVO-009

Application context (from source-drug indications)

Major depressive disorderLevomilnacipran HydrochlorideIschaemic strokeLevomilnacipran HydrochlorideDepressionLevomilnacipran Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Levomilnacipran Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Levomilnacipran HydrochlorideProcess routesteps: 7total yield: 41 kg

(R)-2-(chloromethyl)oxirane→2-phenylacetonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid→(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one→(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide→(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide→potassium 1,3-dioxoisoindolin-2-ide→(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

Levomilnacipran HydrochlorideOptimised routesteps: 11total yield: /

(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one→LEVO-009→LEVO-016→LEVO-017→LEVO-018→LEVO-019→LEVO-020→LEVO-021→LEVO-022→LEVO-023→LEVO-024→LEVO-025→LEVO-026

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