CAS 17609-80-2

4-amino-3-chlorophenol

Codes: LENT-009

Application context (from source-drug indications)

Renal cell carcinomaLenvatinib MesilateEndometrial cancerLenvatinib MesilateHepatocellular carcinomaLenvatinib MesilateThyroid cancerLenvatinib Mesilate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Lenvatinib Mesilate	Tier A — Act now	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Lenvatinib MesilateOriginator routesteps: 9total yield: 22.4 mg

4-amino-2-chlorobenzonitrile→4-amino-2-methoxybenzonitrile→5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione→4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid→4-chloro-7-methoxyquinoline-6-carbonyl chloride→4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide→phenyl carbonochloridate→phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→cyclopropanamine

Lenvatinib MesilateProcess routesteps: 4total yield: 7.78 kg

4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→phenyl carbonochloridate→cyclopropanamine→phenyl (2-chloro-4-hydroxyphenyl)carbamate→1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea

Lenvatinib MesilateOptimised routesteps: 4total yield: 59.4 g

4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→cyclopropanamine→tert-butyl (2-chloro-4-hydroxyphenyl)carbamate→tert-butyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide hydrochloride

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	4-Amino-3-chlorophenol Pharmaceutical Intermediates	On request	On request	On request	—

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